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The Isère (US: ee-ZAIR, French: [izɛʁ] ; Arpitan: Isera; Occitan: Isèra) is a river in the Auvergne-Rhône-Alpes region of southeastern France. Its source, a glacier known as the Sources de l'Isère, lies in the Vanoise National Park in the Graian Alps of Savoie, near the ski resort in Val-d'Isère on the border with Italy.

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An important left-bank tributary of the Rhône, the Isère merges with it a few kilometers north of Valence. Many riverside communes have incorporated the Isère's name into their own, for example, Sainte-Hélène-sur-Isère and Romans-sur-Isère. The department of Isère is likewise named after the river.